A family of algebraic curves covering a projective variety $X$ is called a web of curves on $X$ if it has only finitely many members through a general point of $X$. A web of curves on $X$ induces a web-structure, in the sense of local differential geometry, in a neighborhood of a general point of $X$. We study how the local differential geometry of the web-structure affects the global algebraic geometry of $X$. Under two geometric assumptions on the web-structure, the pairwise non-integrability condition and the bracket-generating condition, we prove that the local differential geometry determines the global algebraic geometry of $X$, up to generically finite algebraic correspondences. The two geometric assumptions are satisfied, for example, when $X subset {bf P}^N$ is a Fano submanifold of Picard number 1, and the family of lines covering $X$ becomes a web. In this special case, we have a stronger result that the local differential geometry of the web-structure determines $X$ up to biregular equivalences. As an application, we show that if $X, X subset {bf P}^N, dim X geq 3,$ are two such Fano manifolds of Picard number 1, then any surjective morphism $f: X to X$ is an isomorphism.
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