Given a hypergraph $H$ and a weight function $w: V rightarrow {1, dots, M}$ on its vertices, we say that $w$ is isolating if there is exactly one edge of minimum weight $w(e) = sum_{i in e} w(i)$. The Isolation Lemma is a combinatorial principle introduced in Mulmuley et. al (1987) which gives a lower bound on the number of isolating weight functions. Mulmuley used this as the basis of a parallel algorithm for finding perfect graph matchings. It has a number of other applications to parallel algorithms and to reductions of general search problems to unique search problems (in which there are one or zero solutions). The original bound given by Mulmuley et al. was recently improved by Ta-Shma (2015). In this paper, we show improved lower bounds on the number of isolating weight functions, and we conjecture that the extremal case is when $H$ consists of $n$ singleton edges. When $M gg n$ our improved bound matches this extremal case asymptotically. We are able to show that this conjecture holds in a number of special cases: when $H$ is a linear hypergraph or is 1-degenerate, or when $M = 2$. We also show that it holds asymptotically when $M gg n gg 1$.
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