Lagrangian descriptions of irreducible and reducible integer higher-spin representations of the Poincare group subject to a Young tableaux $Y[hat{s}_1,hat{s}_2]$ with two columns are constructed within a metric-like formulation in a $d$-dimensional flat space-time on the basis of a BRST approach extending the results of [arXiv:1412.0200[hep-th]]. A Lorentz-invariant resolution of the BRST complex within both the constrained and unconstrained BRST formulations produces a gauge-invariant Lagrangian entirely in terms of the initial tensor field $Phi_{[mu]_{hat{s}_1}, [mu]_{hat{s}_2}}$ subject to $Y[hat{s}_1,hat{s}_2]$ with an additional tower of gauge parameters realizing the $(hat{s}_1-1)$-th stage of reducibility with a specific dependence on the value $(hat{s}_1-hat{s}_2)=0,1,...,hat{s}_1$. Minimal BRST--BV action is suggested, being proper solution to the master equation in the minimal sector and providing objects appropriate to construct interacting Lagrangian formulations with mixed-antisymmetric fields in a general framework.