We propose the left-right models based on SU(3)_Cotimes SU(M)_L otimes SU(N)_R otimes U(1)_X gauge symmetry for (M,N)=(3,3), (2,3), and (3,2) that address the 750 GeV diphoton excess recently reported by the LHC. The fermion contents are minimally introduced, and the generation number must match the fundamental color number to cancel anomalies and ensure QCD asymptotic freedom. The diphoton excess arises from the field that breaks the left-right symmetry spontaneously in the first model, while for the last models it emerges as an explicit violation of the left-right symmetry. The neutrino masses, flavor-changing neutral currents, and new boson searches are also discussed.