Some very large (>0.1 um) presolar grains are sampled in meteorites. We reconsider the lifetime of very large grains (VLGs) in the interstellar medium focusing on interstellar shattering caused by turbulence-induced large velocity dispersions. This path has never been noted as a dominant mechanism of destruction. We show that, if interstellar shattering is the main mechanism of destruction of VLGs, their lifetime is estimated to be $gtrsim 10^8$ yr; in particular, very large SiC grains can survive cosmic-ray exposure time. However, most presolar SiC grains show residence times significantly shorter than 1 Gyr, which may indicate that there is a more efficient mechanism than shattering in destroying VLGs, or that VLGs have larger velocity dispersions than 10 km s$^{-1}$. We also argue that the enhanced lifetime of SiC relative to graphite can be the reason why we find SiC among $mu$m-sized presolar grains, while the abundance of SiC in the normal interstellar grains is much lower than graphite.
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