In this paper, we prove the real-rootedness of two classes of generalized Narayana polynomials: one arising as the $h$-polynomials of the generalized associahedron associated to the finite Weyl groups, the other arising in the study of the infinite log-concavity of the Boros-Moll polynomials. For the former, Br{a}nd{e}n has already proved that these $h$-polynomials have only real zeros. We establish certain recurrence relations for the two classes of Narayana polynomials, from which we derive the real-rootedness. To prove the real-rootedness, we use a sufficient condition, due to Liu and Wang, to determine whether two polynomials have interlaced zeros. The recurrence relations are verified with the help of the Mathematica package textit{HolonomicFunctions}.
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