Demand response (DR) is becoming increasingly important as the volatility on the grid continues to increase. Current DR approaches are completely manual and rule-based or involve deriving first principles based models which are extremely cost and time prohibitive to build. We consider the problem of data-driven end-user DR for large buildings which involves predicting the demand response baseline, evaluating fixed rule based DR strategies and synthesizing DR control actions. We provide a model based control with regression trees algorithm (mbCRT), which allows us to perform closed-loop control for DR strategy synthesis for large commercial buildings. Our data-driven control synthesis algorithm outperforms rule-based DR by $17%$ for a large DoE commercial reference building and leads to a curtailment of $380$kW and over $$45,000$ in savings. Our methods have been integrated into an open source tool called DR-Advisor, which acts as a recommender system for the buildings facilities manager and provides suitable control actions to meet the desired load curtailment while maintaining operations and maximizing the economic reward. DR-Advisor achieves $92.8%$ to $98.9%$ prediction accuracy for 8 buildings on Penns campus. We compare DR-Advisor with other data driven methods and rank $2^{nd}$ on ASHRAEs benchmarking data-set for energy prediction.