We report on a search for monochromatic $gamma$-ray features in the spectra of galaxy clusters observed by the emph{Fermi} Large Area Telescope. Galaxy clusters are the largest structures in the Universe that are bound by dark matter (DM), making them an important testing ground for possible self-interactions or decays of the DM particles. Monochromatic $gamma$-ray lines provide a unique signature due to the absence of astrophysical backgrounds and are as such considered a smoking-gun signature for new physics. An unbinned joint likelihood analysis of the sixteen most promising clusters using five years of data at energies between 10 and 400 GeV revealed no significant features. For the case of self-annihilation, we set upper limits on the monochromatic velocity-averaged interaction cross section. These limits are compatible with those obtained from observations of the Galactic Center, albeit weaker due to the larger distance to the studied clusters.