We investigate the gamma-ray and X-ray properties of the flat spectrum radio quasar PKS 2149-306 at redshift z = 2.345. A strong gamma-ray flare from this source was detected by the Large Area Telescope on board the Fermi Gamma-ray Space Telescope satellite in 2013 January, reaching on January 20 a daily peak flux of (301$pm$36)$times$10$^{-8}$ ph/cm$^2$/s in the 0.1-100 GeV energy range. This flux corresponds to an apparent isotropic luminosity of (1.5$pm$0.2)$times$10$^{50}$ erg/s, comparable to the highest values observed by a blazar so far. During the flare the increase of flux was accompanied by a significant change of the spectral properties. Moreover significant flux variations on a 6-h time-scale were observed, compatible with the light crossing time of the event horizon of the central black hole. The broad band X-ray spectra of PKS 2149-306 observed by Swift-XRT and NuSTAR are well described by a broken power-law model, with a very hard spectrum ($Gamma$$_1$ $sim$ 1) below the break energy, at E$_{rm,break}$ = 2.5-3.0 keV, and $Gamma$$_2$ $sim$ 1.4-1.5 above the break energy. The steepening of the spectrum below $sim$ 3 keV may indicate that the soft X-ray emission is produced by the low-energy relativistic electrons. This is in agreement with the small variability amplitude and the lack of spectral changes in that part of the X-ray spectrum observed between the two NuSTAR and Swift joint observations. As for the other high-redshift FSRQ detected by both Fermi-LAT and Swift-BAT, the photon index of PKS 2149-306 in hard X-ray is 1.6 or lower and the average gamma-ray luminosity higher than 2$times$10$^{48}$ erg/s.
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