The idea of topological quantum computation (TQC) is to store and manipulate quantum information in an intrinsically fault-tolerant manner by utilizing the physics of topologically ordered phases of matter. Currently, one of the most promising platforms for a topological qubit is in terms of Majorana fermion zero modes (MZMs) in spin-orbit coupled superconducting nanowires. However, the topologically robust operations that are possible with MZMs can be efficiently simulated on a classical computer and are therefore not sufficient for realizing a universal gate set for TQC. Here, we show that an array of coupled semiconductor-superconductor nanowires with MZM edge states can be used to realize a more sophisticated type of non-Abelian defect: a genon in an Ising $times$ Ising topological state. This leads to a possible implementation of the missing topologically protected $pi/8$ phase gate and thus universal TQC based on semiconductor-superconductor nanowire technology. We provide detailed numerical estimates of the relevant energy scales, which we show to lie within accessible ranges.