The Cherenkov Telescope Array (CTA) is an international project for a next-generation ground-based gamma-ray observatory. CTA, conceived as an array of tens of imaging atmospheric Cherenkov telescopes, comprising small, medium and large-size telescopes, is aiming to improve on the sensitivity of current-generation experiments by an order of magnitude and provide energy coverage from 20 GeV to more than 300 TeV. In this study we explore how the medium-sized telescopes layout design and composition impacts the overall CTA performance by analyzing Monte Carlo simulations including Davies-Cotton and Schwarzschild-Couder medium-sized telescopes.