The DD-reaction is investigated and the heat emission off the targets during their irradiation with ion beams is studied at the HELIS ion accelerator at LPI. The heat emission is observed to be significantly higher in the case of irradiation of the Ti/TiO2:Dx-targets by a D+ beam, as compared to the H+ and Ne+ beams. Furthermore, it depends on the concentration of deuterium in the target and current density of the deuteron beam.