Let $Gamma_d(q)$ denote the group whose Cayley graph with respect to a particular generating set is the Diestel-Leader graph $DL_d(q)$, as described by Bartholdi, Neuhauser and Woess. We compute both $Aut(Gamma_d(q))$ and $Out(Gamma_d(q))$ for $d geq 2$, and apply our results to count twisted conjugacy classes in these groups when $d geq 3$. Specifically, we show that when $d geq 3$, the groups $Gamma_d(q)$ have property $R_{infty}$, that is, every automorphism has an infinite number of twisted conjugacy classes. In contrast, when $d=2$ the lamplighter groups $Gamma_2(q)=L_q = {mathbb Z}_q wr {mathbb Z}$ have property $R_{infty}$ if and only if $(q,6) eq 1$.
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