On the basis of the Brueckner-Hartree-Fock method with the nucleon-nucleon forces obtained from lattice QCD simulations, the properties of the medium-heavy doubly-magic nuclei such as 16^O and 40^Ca are investigated. We found that those nuclei are bound for the pseudo-scalar meson mass M_PS ~ 470 MeV. The mass number dependence of the binding energies, single-particle spectra and density distributions are qualitatively consistent with those expected from empirical data at the physical point, although these hypothetical nuclei at heavy quark mass have smaller binding energies than the real nuclei.