We study a realistic top-down M-theory compactification with low-scale effective Supersymmetry, consistent with phenomenological constraints. A combination of top-down and generic phenomenological constraints fix the spectrum. The gluino mass is predicted to be about 1.5 TeV. Three and only three superpartner channels, $tilde{g} tilde{g}$, $chi_2^0 chi_1^pm$ and $chi_1^+ chi_1^-$ (where $chi_2^0, chi_1^pm$ are Wino-like), are expected to be observable at LHC-14. We also investigate the prospects of finding heavy squarks and Higgsinos at future colliders. Gluino-stop-top, gluino-sbottom-bottom associated production and first generation squark associated production should be observable at a 100 TeV collider, along with direct production of heavy Higgsinos. Within this framework the discovery of a single sparticle is sufficient to determine uniquely the SUSY spectrum, yielding a number of concrete testable predictions for LHC-14 and future colliders, and determination of $M_{3/2}$ and thereby other fundamental quantities.