We study the scattering of matter-waves from interacting bosons in a one-dimensional optical lattice, described by the Bose-Hubbard Hamiltonian. We derive analytically a formula for the inelastic cross section as a function of the atomic interaction in the lattice, employing Bogoliubovs formalism for small condensate depletion. A linear decay of the inelastic cross section for weak interaction, independent of number of particles, condensate depletion and system size, is found.