We study intersecting brane systems that realize a class of singular monopole configurations in four-dimensional Yang-Mills-Higgs theory. Singular monopoles are solutions to the Bogomolny equation on R^3 with a prescribed number of singularities corresponding to the insertion of t Hooft defects. We use the brane construction to motivate a recent conjecture on the conditions for which the moduli space of solutions is non-empty. We also show how branes provide physical intuition for various aspects of the dimension formula derived in {arXiv:1404.5616}, including the contribution to the dimension from the defects and its invariance under Weyl reflections of the t Hooft charges. Along the way we uncover and illustrate new dynamical phenomena for the brane systems, including a description of smooth monopole extraction and bubbling from t Hooft defects.
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