We report the first measurement of charmed-hadron ($D^0$) production via the hadronic decay channel ($D^0rightarrow K^- + pi^+$) in Au+Au collisions at $sqrt{s_{_{mathrm{NN}}}}$ = 200,GeV with the STAR experiment. The charm production cross-section per nucleon-nucleon collision at mid-rapidity scales with the number of binary collisions, $N_{bin}$, from $p$+$p$ to central Au+Au collisions. The $D^0$ meson yields in central Au+Au collisions are strongly suppressed compared to those in $p$+$p$ scaled by $N_{bin}$, for transverse momenta $p_{T}>3$ GeV/$c$, demonstrating significant energy loss of charm quarks in the hot and dense medium. An enhancement at intermediate $p_{T}$ is also observed. Model calculations including strong charm-medium interactions and coalescence hadronization describe our measurements.
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