We consider flavor constraints on, and collider signatures of, Asymmetric Dark Matter (ADM) via higher dimension operators. In the supersymmetric models we consider, R-parity violating (RPV) operators carrying B-L interact with n dark matter (DM) particles X through an interaction of the form W = X^n O_{B-L}, where O_{B-L} = q l d^c, u^c d^c d^c, l l e^c. This interaction ensures that the lightest ordinary supersymmetric particle (LOSP) is unstable to decay into the X sector, leading to a higher multiplicity of final state particles and reduced missing energy at a collider. Flavor-violating processes place constraints on the scale of the higher dimension operator, impacting whether the LOSP decays promptly. While the strongest limitations on RPV from n-bar{n} oscillations and proton decay do not apply to ADM, we analyze the constraints from meson mixing, mu-e conversion, mu -> 3 e and b -> s l^+ l^-. We show that these flavor constraints, even in the absence of flavor symmetries, allow parameter space for prompt decay to the X sector, with additional jets and leptons in exotic flavor combinations. We study the constraints from existing 8 TeV LHC SUSY searches with (i) 2-6 jets plus missing energy, and (ii) 1-2 leptons, 3-6 jets plus missing energy, comparing the constraints on ADM-extended supersymmetry with the usual supersymmetric simplified models.