We observe the emergence of a disorder-induced insulating state in a strongly interacting atomic Fermi gas trapped in an optical lattice. This closed quantum system free of a thermal reservoir realizes the disordered Fermi-Hubbard model, which is a minimal model for strongly correlated electronic solids. In measurements of disorder-induced localization obtained via mass transport, we detect interaction-driven delocalization and localization that persists as the temperature of the gas is raised. These behaviors are consistent with many-body localization, which is a novel paradigm for understanding localization in interacting quantum systems at non-zero temperature.
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