This Topical Issue of Solar Physics, devoted to the study of flux-rope structure in coronal mass ejections (CMEs), is based on two Coordinated Data Analysis Workshops (CDAWs) held in 2010 (20 - 23 September in Dan Diego, California, USA) and 2011 (September 5-9 in Alcala, Spain). The primary purpose of the CDAWs was to address the question: Do all CMEs have flux rope structure? There are 18 papers om this topical issue, including this preface.