We employ a SUSY-model-independent method to examine the remaining evidence for the low mass dark matter. Using the XENON100s recent result of 224.6 live days $times$ 34kg exposure and PICASSOs result published in 2009, we have obtained a constrain of couplings, $| {{a_n}} | < 0.6$ and $| {{a_p}} | < 1.0$, corresponding to the spin-dependent cross section of ${sigma_n} < 5.6 times {10^{- 38}}$cm$^{2}$ and ${sigma_p} < 1.6 times {10^{- 37}}$cm$^{2}$. Spin-independent isospin violating dark matter model also failed to reconcile the recent result from XENON100 with the positive results from DAMA and CoGeNT.