We study how macroscopic superpositions of coherent states produced by the nondissipative dynamics of binary mixtures of ultracold atoms are affected by atom losses. We identify different decoherence scenarios for symmetric or asymmetric loss rates and interaction energies in the two modes. In the symmetric case the quantum coherence in the superposition is lost after a single loss event. By tuning appropriately the energies we show that the superposition can be protected, leading to quantum correlations useful for atom interferometry even after many loss events.