Using the data from the Large Area Telescope on board the Fermi Gamma-ray Space Telescope, we have searched for the gamma-ray pulsations from the direction of globular cluster M28 (NGC 6626). We report the discovery of a signal with the frequency consistent with that of the energetic millisecond pulsar (MSP) PSR B1821-24 in M28. A weighted H-test test statisic (TS) of 28.8 is attained which corresponds to a chance probability of ~1e-5 (4.3-sigma detection). With a phase-resolved analysis, the pulsed component is found to contribute ~25% of the total observed gamma-ray emission from the cluster. On the other hand, the unpulsed level provides a constraint for the underlying MSP population and the fundamental plane relations for the scenario of inverse Compton scattering. Follow-up timing observations in radio/X-ray are encouraged for further investigating this periodic signal candidate.