In this article we present a review of the structure of the proton and the current status of our knowledge of the parton distribution functions (PDFs). The lepton-nucleon scattering experiments which provide the main constraints in PDF extractions are introduced and their measurements are discussed. Particular emphasis is given to the HERA data which cover a wide kinematic region. Hadron-hadron scattering measurements which provide supplementary information are also discussed. The methods used by various groups to extract the PDFs in QCD analyses of hard scattering data are presented and their results are compared. The use of existing measurements allows predictions for cross sections at the LHC to be made. A comparison of these predictions for selected processes is given. First measurements from the LHC experiments are compared to predictions and some initial studies of the impact of this new data on the PDFs are presented.
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