We derive the exact supergravity profile for the twisted scalar field emitted by a system of fractional D3 branes at a Z2 orbifold singularity supporting N=2 quiver gauge theories with unitary groups and bifundamental matter. At the perturbative level this twisted field is dual to the gauge coupling but it is corrected non-perturbatively by an infinite tower of fractional D-instantons. The explicit microscopic description allows to derive the gravity profile from disk amplitudes computing the emission rate of the twisted scalar field in terms of chiral correlators in the dual gauge theory. We compute these quantum correlators using multi-instanton localization techniques and/or Seiberg-Witten analysis. Finally, we discuss a non-perturbative relation between the twisted scalar and the effective coupling of the gauge theory for some simple choices of the brane set ups.
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