The present work reports on an extended research endeavor focused on the theoretical and experimental realization of a macroscopic quantum superposition (MQS) made up with photons. As it is well known, this intriguing, fundamental quantum condition is at the core of a famous argument conceived by Erwin Schroedinger, back in 1935. The main experimental challenge to the actual realization of this object resides generally on the unavoidable and uncontrolled interactions with the environment, i.e. the decoherence leading to the cancellation of any evidence of the quantum features associated with the macroscopic system. The present scheme is based on a nonlinear process, the quantum injected optical parametric amplification, that maps by a linearized cloning process the quantum coherence of a single - particle state, i.e. a Micro - qubit, into a Macro - qubit, consisting in a large number M of photons in quantum superposition. Since the adopted scheme was found resilient to decoherence, the MQS demonstration was carried out experimentally at room temperature with $Mgeq $ $10^{4}$. This result elicited an extended study on quantum cloning, quantum amplification and quantum decoherence. The related theory is outlined in the article where several experiments are reviewed such as the test on the no-signaling theorem and the dynamical interaction of the photon MQS with a Bose-Einstein condensate. In addition, the consideration of the Micro - Macro entanglement regime is extended into the Macro - Macro condition. The MQS interference patterns for large M were revealed in the experiment and the bipartite Micro-Macro entanglement was also demonstrated for a limited number of generated particles: $Mprecsim 12$. At last, the perspectives opened by this new method are considered in the view of further studies on quantum foundations and quantum measurement.
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