Superconducting qubits acting as artificial two-level atoms allow for controlled variation of the symmetry properties which govern the selection rules for single and multiphoton excitation. We spectroscopically analyze a superconducting qubit-resonator system in the strong coupling regime under one- and two-photon driving. Our results provide clear experimental evidence for the controlled transition from an operating point governed by dipolar selection rules to a regime where one- and two-photon excitations of the artificial atom coexist. We find that the vacuum coupling between qubit and resonator can be straightforwardly extracted from the two-photon spectra where the detuned two-photon drive does not populate the relevant resonator mode significantly.