In this paper we study the one-loop evolution equation of the Higgs quartic coupling $lambda$ in the minimal Universal Extra Dimension model, and find that there are certain bounds on the extra dimension due to the singularity and vacuum stability conditions of the Higgs sector. In the range $250GeV sim {R^{- 1}} sim 80TeV$ of the compactification radius, we notice that for a given initial value $lambda ({M_Z})$, there is an upper limit on ${R^{- 1}}$ for a Higgs mass of $183GeV sim {m_H}({M_Z}) sim 187GeV$; where any other compactification scales beyond that have been ruled out for theories where the evolution of $lambda$ does not develop a Landau pole and become divergent in the whole range (that is, from the electroweak scale to the unification scale). Likewise, in the range of the Higgs mass $152GeV sim {m_H}({M_Z}) sim 157GeV$, for an initial value $lambda ({M_Z})$, we are led to a lower limit on ${R^{- 1}}$; any other compactification scales below that will be ruled out for theories where the evolution of $lambda$ does not become negative and destabilize the vacuum between the electroweak scale and the unification scale. For a Higgs mass in the range $157GeV < {m_H}({M_Z}) < 183GeV$, the evolution of $lambda$ is finite and the theory is valid in the whole range (from the electroweak scale to the unification scale) for $250GeV sim {R^{- 1}} sim 80TeV$.
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