We study RG flow solutions in (1,0) six dimensional supergravity coupled to an anti-symmetric tensor and Yang-Mills multiplets corresponding to a semisimple group $G$. We turn on $G$ instanton gauge fields, with instanton number $N$, in the conformally flat part of the 6D metric. The solution interpolates between two (4,0) supersymmetric $AdS_3times S^3$ backgrounds with two different values of $AdS_3$ and $S^3$ radii and describes an RG flow in the dual 2D SCFT. For the single instanton case and $G=SU(2)$, there exist a consistent reduction ansatz to three dimensions, and the solution in this case can be interpreted as an uplifted 3D solution. Correspondingly, we present the solution in the framework of N=4 $(SU(2)ltimes mathbf{R}^3)^2$ three dimensional gauged supergravity. The flows studied here are of v.e.v. type, driven by a vacuum expectation value of a (not exactly) marginal operator of dimension two in the UV. We give an interpretation of the supergravity solution in terms of the D1/D5 system in type I string theory on K3, whose effective field theory is expected to flow to a (4,0) SCFT in the infrared.
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