It is difficult to reconcile the observed evolution of the star formation rate versus stellar mass (SFR-M*) relation with expectations from current hierarchical galaxy formation models. The observed SFR-M* relation shows a rapid rise in SFR(M*) from z=0-2, and then a surprisingly lack of amplitude evolution out to z~6+. Hierarchical models of galaxy formation match this trend qualitatively but not quantitatively, with a maximum discrepancy of ~x3 in SFR at z~2. One explanation, albeit radical, is that the IMF becomes modestly weighted towards massive stars out to z~2, and then evolves back towards its present-day form by z~4 or so. We observe that this redshift trend mimics that of the cosmic fraction of obscured star formation, perhaps hinting at a physical connection. Such IMF evolution would concurrently go towards explaining persistent discrepancies between integrated measures of star formation and present-day stellar mass or cosmic colors.