The work by Christandl, Konig and Renner [Phys. Rev. Lett. 102, 020504 (2009)] provides in particular the possibility of studying unconditional security in the finite-key regime for all discrete-variable protocols. We spell out this bound from their general formalism. Then we apply it to the study of a recently proposed protocol [Laing et al., Phys. Rev. A 82, 012304 (2010)]. This protocol is meaningful when the alignment of Alices and Bobs reference frames is not monitored and may vary with time. In this scenario, the notion of asymptotic key rate has hardly any operational meaning, because if one waits too long time, the average correlations are smeared out and no security can be inferred. Therefore, finite-key analysis is necessary to find the maximal achievable secret key rate and the corresponding optimal number of signals.
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