This article presents and grounds (i.e. presents proof of the existence, the truth, the self-consistence and the completeness of)the informational conception (the Information as Absolute conception)in physics and philosophy. the conception defines the information as an ultimately common, real and fundamental concept/phenomenon - Absolute, which exists as anabsolutely infinite set (Information Set) of elements (members) and informational (e.g., logical) linksbetween the elements; where any element itself is some informational structure also. Correspondingly, for example, Matter as the substence, radiation, etc., is some development or realization of informational patterns, constituting a specific - and practically infinitesimal comparing to the Set - subset of the Information Set. The conception allows for the resolution, or at least for a consideration on a higher level of comprehension, of the basic ontological and epistemological problems in philosophy and natural sciences; in physics it allows to suggest reasonable model, which makes more clear basic phisical notions,such as space, time, matter, etc.