We study the self adjoint extensions of a class of non maximal multiplication operators with boundary conditions. We show that these extensions correspond to singular rank one perturbations (in the sense of cite{AK}) of the Laplace operator, namely the formal Laplacian with a singular delta potential, on the half space. This construction is the appropriate setting to describe the Casimir effect related to a massless scalar field in the flat space time with an infinite conducting plate and in the presence of a point like impurity. We use the relative zeta determinant (as defined in cite{Mul} and cite{SZ}) in order to regularize the partition function of this model. We study the analytic extension of the associated relative zeta function, and we present explicit results for the partition function, and for the Casimir force.
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