It is well known from numerous experiments that nuclear multifragmentation is a dominating mechanism for production of intermediate-mass fragments in nucleus-nucleus collisions at energies above 100 A MeV. In this paper we investigate the validity and performance of the Fermi break-up model and the statistical multifragmentation model implemented as parts of the Geant4 toolkit. We study the impact of violent nuclear disintegration reactions on the depth-dose profiles and yields of secondary fragments for beams of light and medium-weight nuclei propagating in extended media. Implications for ion-beam cancer therapy and shielding from cosmic radiation are discussed.
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