Among the newly discovered features of multiple stellar populations in Globular Clusters, the cluster NGC 1851 harbours a double subgiant branch, that can be explained in terms of two stellar generations, only slightly differing in age, the younger one having an increased total C+N+O abundance. Thanks to this difference in the chemistry, a fit can be made to the subgiant branches, roughly consistent with the C+N+O abundance variations already discovered two decades ago, and confirmed by recent spectroscopic data. We compute theoretical isochrones for the main sequence turnoff, by adopting four chemical mixtures for the opacities and nuclear reaction rates. The standard mixture has Z=10$^{-3}$ and [$alpha$/Fe]=0.4, the others have C+N+O respectively equal to 2, 3 and 5 times the standard mixture, according to the element abundance distribution described in the text. We compare tracks and isochrones, and show how the results depend on the total CNO abundance. We notice that different initial CNO abundances between two clusters, otherwise similar in metallicity and age, may lead to differences in the turnoff morphology that can be easily attributed to an age difference. We simulate the main sequence and subgiant branch data for NGC 1851 and show that an increase of C+N+O by a factor $sim$3 best reproduces the shift between the subgiant branches. We compare the main sequence width in the color m$_{F336W}$-m$_{F814W}$ with models, and find that the maximum helium abundance compatible with the data is Y$simeq$0.29. We consider the result in the framework of the formation of the second stellar generation in globular clusters, for the bulk of which we estimate a helium abundance of Y$simlt 0.26$.
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