Prospective searches about Higgs physics and beyond the Standard Model are presented for the CMS and ATLAS experiments. Possible excesses of events in real data could be an indication of the existence of new particles, even with few hundred pb-1 of integrated luminosity. In this paper the focus is on the current analyses strategies and on the potential both for a discovery and/or for an exclusion of the Standard Model Higgs boson in the main decay channels. The searches for some supersymmetric and exotic particles predicted by several theoretical models are also discussed.