We study isospin effects in semi-peripheral collisions above the Fermi energy by considering the symmetric $^{58}Ni$ + $^{58}Ni$ and the asymmetric reactions $^{58}Ni$ + $^{197}Au$ over the incident energy range 52-74 A MeV. A microscopic transport model with two different parameterizations of the symmetry energy term is used to investigate the isotopic content of pre-equilibrium emission and the N/Z diffusion process. Simulations are also compared to experimental data obtained with the INDRA array and bring information on the degree of isospin equilibration observed in Ni + Au collisions. A better overall agreement between data and simulations is obtained when using a symmetry term which linearly increases with nuclear density.
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