We present a model for electron- and neutrino-scattering off nucleons and nuclei focussing on the quasielastic and resonance region. The lepton-nucleon reaction is described within a relativistic formalism that includes, besides quasielastic scattering, the excitation of 13 N* and Delta resonances and a non-resonant single-pion background. Recent electron-scattering data is used for the state-of-the-art parametrizations of the vector form factors; the axial couplings are determined via PCAC and, in the case of the Delta resonance, the axial form factor is refitted using neutrino-scattering data. Scattering off nuclei is treated within the GiBUU framework that takes into account various nuclear effects: the local density approximation for the nuclear ground state, mean-field potentials and in-medium spectral functions. Results for inclusive scattering off Oxygen are presented and, in the case of electron-induced reactions, compared to experimental data and other models.