By application of the general twist-induced star-deformation procedure we translate second quantization of a system of bosons/fermions on a symmetric spacetime in a non-commutative language. The procedure deforms in a coordinated way the spacetime algebra and its symmetries, the wave-mechanical description of a system of n bosons/fermions, the algebra of creation and annihilation operators and also the commutation relations of the latter with functions of spacetime; our key requirement is the mode-decomposition independence of the quantum field. In a conservative view, the use of noncommutative coordinates can be seen just as a way to better express non-local interactions of a special kind. In a non-conservative one, we obtain a covariant framework for QFT on the corresponding noncommutative spacetime consistent with quantum mechanical axioms and Bose-Fermi statistics. One distinguishing feature is that the field commutation relations remain of the type field (anti)commutator=a distribution. We illustrate the results by choosing as examples interacting non-relativistic and free relativistic QFT on Moyal space(time)s.
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