Let $D$ be an unbounded domain in $RR^d$ with $dgeq 3$. We show that if $D$ contains an unbounded uniform domain, then the symmetric reflecting Brownian motion (RBM) on $overline D$ is transient. Next assume that RBM $X$ on $overline D$ is transient and let $Y$ be its time change by Revuz measure ${bf 1}_D(x) m(x)dx$ for a strictly positive continuous integrable function $m$ on $overline D$. We further show that if there is some $r>0$ so that $Dsetminus overline {B(0, r)}$ is an unbounded uniform domain, then $Y$ admits one and only one symmetric diffusion that genuinely extends it and admits no killings. In other words, in this case $X$ (or equivalently, $Y$) has a unique Martin boundary point at infinity.