A class of multidimensional integrable hierarchies connected with commutation of general (unreduced) (N+1)-dimensional vector fields containing derivative over spectral variable is considered. They are represented in the form of generating equation, as well as in the Lax-Sato form. A dressing scheme based on nonlinear vector Riemann problem is presented for this class. The hierarchies connected with Manakov-Santini equation and Dunajski system are considered as illustrative examples.