I discuss advances in the determination of strange, charm, and bottom quark parton distribution functions obtained in the CTEQ6.5 and CTEQ6.6 global analyses. These results affect electroweak precision observables and certain new physics searches at the Large Hadron Collider. I focus, in particular, on high-energy implications of the consistent treatment of heavy-quark threshold effects in DIS in the general-mass factorization scheme; an independent parametrization for the strangeness PDF; and the possible presence of nonperturbative (intrinsic) charm.
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