In three previous papers by the two first authors, classes of initial data to the three dimensional, incompressible Navier-Stokes equations were presented, generating a global smooth solution although the norm of the initial data may be chosen arbitrarily large. The main feature of the initial data considered in the last paper is that it varies slowly in one direction, though in some sense it is ``well prepared (its norm is large but does not depend on the slow parameter). The aim of this article is to generalize the setting of that last paper to an ``ill prepared situation (the norm blows up as the small parameter goes to zero).The proof uses the special structure of the nonlinear term of the equation.