String instanton effects in Higgs physics are discussed through a type IIA model based on T^{6}/(Z^{2}times Z^{2}) orentifold compactifaction. By inclusion of rigid E2-branes, the model exhibits a MSSM-like spectrum, as well as extra mu and quartic Higgs couplings. These extra couplings are induced via E2 instantons non-perturbatively. Setting the string scale at 10^{18} GeV, one gets interesting TeV Higgs physics. In particlular, the tree-level Higgs mass can be uplifted substantially.
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