The search for stable heavy exotic hadrons is a promising way to observe new physics processes at collider experiments. The discovery potential for such particles can be enhanced or suppressed by their interactions with detector material. This paper describes a model for the interactions in matter of stable hadrons containing an exotic quark of charges $pm {1/3}e$ or $pm {2/3}e$ using Regge phenomenology and the Quark Gluon String Model. The influence of such interactions on searches at the LHC is also discussed.