Building on work by Geiss-Leclerc-Schroer and by Buan-Iyama-Reiten-Scott we investigate the link between certain cluster algebras with coefficients and suitable 2-Calabi-Yau categories. These include the cluster-categories associated with acyclic quivers and certain Frobenius subcategories of module categories over preprojective algebras. Our motivation comes from the conjectures formulated by Fomin and Zelevinsky in `Cluster algebras IV: Coefficients. We provide new evidence for Conjectures 5.4, 6.10, 7.2, 7.10 and 7.12 and show by an example that the statement of Conjecture 7.17 does not always hold.
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