We employed an electrically-driven polarization controller to implement anisotropic depolarizing quantum channels for the polarization state of single photons. The channels were characterized by means of ancilla-assisted quantum process tomography using polarization-entangled photons generated in the process of spontaneous parametric down-conversion. The demonstrated depolarization method offers good repeatability, low cost, and compatibility with fiber-optic setups. It does not perturb the modal structure of single photons, and therefore can be used to verify experimentally protocols for managing decoherence effects based on multiphoton interference.