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Single species population models and discrete stochastic gene frequency models are two standards of mathematical biology important for the evolution of populations. An agent based model is presented which reproduces these models and then explores where these models agree and disagree under relaxed specifications. For the population models, the requirement of homogeneous mixing prevents prediction of extinctions due to local resource depletion. These models also suggest equilibrium based on attainment of constant population levels though underlying population characteristics may be nowhere close to equilibrium. The discrete stochastic gene frequency models assume well mixed populations at constant levels. The models predictions for non-constant populations in strongly oscillating and chaotic regimes are surprisingly good, only diverging from the ABM at the most chaotic levels.
Malaria is a mosquito-borne, lethal disease that affects millions and kills hundreds of thousands of people each year. In this paper, we develop a model for allocating malaria interventions across geographic regions and time, subject to budget constr
We study the effectiveness of tracking and testing in mitigating or suppressing epidemic outbreaks, in combination with or as an alternative to quarantines and global lockdowns. We study these intervention methods on a network-based SEIR model, augme
The human adaptive immune response is known to weaken in advanced age, resulting in increased severity of pathogen-born illness, poor vaccine efficacy, and a higher prevalence of cancer in the elderly. Age-related erosion of the T-cell compartment ha
We present a new mathematical model to explicitly capture the effects that the three restriction measures: the lockdown date and duration, social distancing and masks, and, schools and border closing, have in controlling the spread of COVID-19 infect
It is well-established that including spatial structure and stochastic noise in models for predator-prey interactions invalidates the classical deterministic Lotka-Volterra picture of neutral population cycles. In contrast, stochastic models yield lo