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Accelerated degradation tests are used to provide accurate estimation of lifetime properties of highly reliable products within a relatively short testing time. There data from particular tests at high levels of stress (e.,g. temperature, voltage, or vibration) are extrapolated, through a physically meaningful model, to obtain estimates of lifetime quantiles under normal use conditions. In this work, we consider repeated measures accelerated degradation tests with multiple stress variables, where the degradation paths are assumed to follow a linear mixed effects model which is quite common in settings when repeated measures are made. We derive optimal experimental designs for minimizing the asymptotic variance for estimating the median failure time under normal use conditions when the time points for measurements are either fixed in advance or are also to be optimized.
Accelerated degradation tests are used to provide accurate estimation of lifetime characteristics of highly reliable products within a relatively short testing time. Data from particular tests at high levels of stress (e.g., temperature, voltage, or
Accelerated degradation testing (ADT) is one of the major approaches in reliability engineering which allows accurate estimation of reliability characteristics of highly reliable systems within a relatively short time. The testing data are extrapolat
The ability to generate samples of the random effects from their conditional distributions is fundamental for inference in mixed effects models. Random walk Metropolis is widely used to conduct such sampling, but such a method can converge slowly for
This paper arises from collaborative research the aim of which was to model clinical assessments of upper limb function after stroke using 3D kinematic data. We present a new nonlinear mixed-effects scalar-on-function regression model with a Gaussian
The functional linear model is a popular tool to investigate the relationship between a scalar/functional response variable and a scalar/functional covariate. We generalize this model to a functional linear mixed-effects model when repeated measureme